Vitamin and cholesterol relationship

Relationship between vitamin A and serum HDL cholesterol may protect against heart disease

vitamin and cholesterol relationship

Keywords: Vitamin B12, Folic acid, Cholesterol, Homocysteine, Adipocyte, LDL cholesterol, cholesterol-to-HDL ratio, and homocysteine than. B. Total cholesterol has a weak correlation with cardio vascular events which is why the recommended serum levels keep getting revised. Researchers at the Holy Spirit University of Kaslik in Lebanon conducted a study to analyse the link between vitamin A intake and plasma HDL.

These results guided the investigation into the cellular mechanisms of induced cholesterol biosynthesis due to vitamin B12 deficiency, using human adipocytes as a model system. Adipocytes cultured in low or no vitamin B12 conditions had increased cholesterol and homocysteine levels compared to control.

The induction of cholesterol biosynthesis was associated with reduced s-adenosylmethionine AdoMet -to-s-adenosylhomocysteine AdoHcy ratio, also known as methylation potential MP.

Muscle Aches, Low Cholesterol and Vitamin D Deficiency

We therefore studied whether reduced MP could lead to hypomethylation of genes involved in the regulation of cholesterol biosynthesis. Genome-wide and targeted DNA methylation analysis identified that the promoter regions of SREBF1 and LDLR, two key regulators of cholesterol biosynthesis, were hypomethylated under vitamin Bdeficient conditions, and as a result, their expressions and cholesterol biosynthesis were also significantly increased.

Finally, we observed that the expression of SREBF1, LDLR, and cholesterol biosynthesis genes were increased in adipose tissue of vitamin B12 deficient mothers compared to control group.

Do vitamin D supplements provide the same effect on cholesterol levels as sunlight?

Conclusions Clinical data suggests that vitamin B12 deficiency is an important metabolic risk factor. Regulation of AdoMet-to-AdoHcy levels by vitamin B12 could be an important mechanism by which it can influence cholesterol biosynthesis pathway in human adipocytes.

Electronic supplementary material The online version of this article doi: Vitamin B12, Folic acid, Cholesterol, Homocysteine, Adipocyte, Methylation Background Adipose tissue AT plays a central role in integrating energy metabolism and glucose homeostasis [ 1 ].

In contrast, other specialised cells and tissues store small pools of esterified cholesterol, such as adrenal cells or foam cells, which have the capacity to accumulate considerable quantities of excess cholesterol esters [ 5 ]. A delicate balance exists between uptake, synthesis, and storage which tightly controls the abundance of free cholesterol in peripheral cells [ 6 ] while excess free cholesterol is in fact deleterious to cells [ 7 ].

vitamin and cholesterol relationship

Studies in Zucker rats [ 11 ] and 3T3FA cells [ 12 ] also highlight that with an increase in triglyceride storage, cholesterol is redistributed from the plasma membrane to the surface of the lipid droplet and adipocyte cholesterol levels appear to increase in proportion to the triglyceride content [ 13 ]. There is also accumulating evidence that adipose cholesterol imbalance is closely associated with adipocyte dysfunction and obesity-mediated metabolic complications and insulin resistance [ 91314 ].

Despite the significant physiological importance of adipocyte cholesterol, especially with regard to the reported association between obesity and mortality from cardiovascular diseases [ 15 ], the regulation of de novo synthetic pathway of cholesterol within adipocytes has not been studied in detail. In a prospective, longitudinal study of humans in early pregnancy, vitamin B12 deficiency independently predicted gestational diabetes and type 2 diabetes T2D at 5-year post-delivery.

Some research has even tied it to depression, high blood pressure, cancer, type 2 diabetes, asthma, and high cholesterol. Cholesterol is another necessary substance in the human body. But too much of it can be a bad thing.

Relationship between vitamin A and serum HDL cholesterol may protect against heart disease

There are two main types of cholesterol: Does Vitamin D Lower Cholesterol? There is conflicting information when it comes to the link between cholesterol and vitamin D. One study found that vitamin D supplements have no cholesterol-lowering effects, at least in the short term.

vitamin and cholesterol relationship

In fact, the researchers found that the supplements were actually associated with an increase in LDL. However, research found that taking calcium and vitamin D supplements together improved cholesterol levels in postmenopausal overweight or obese women.

The verdict, according to the National Institutes of Health, is that there is insufficient evidence to determine any relationship between your vitamin D intake and your cholesterol levels.

But with the host of benefits that vitamin D provides to those that use it, there is still no deterrent in using vitamin D as part of your healthy lifestyle. According to the Mayo Clinicvitamin D is safe in doses up to 1, micrograms daily.

Food There are some foods that contain vitamin D.

vitamin and cholesterol relationship

Salmon, tuna, and mackerel are good sources of naturally occurring vitamin D. Trace amounts of vitamin D are found in dairy products and egg yolks. Almost all American milk is fortified with synthetic vitamin D, making dairy products a good source of vitamin D.

Some cereals are also fortified with vitamin D. Check your food labels to see how much vitamin D you are already getting through your diet before using supplements of the vitamin. Sun Exposure Most people get at least some vitamin D through exposure to the sun. Researchers suggest that 30 to 50 minutes outside, three times a week, will give an individual the ideal amount of sun exposure.